Drug â€excipient Interaction of Anti-tubercular Drugs

Drug –excipient Interaction of Anti-tubercular Drugs Drug –excipient interaction of anti-tubercular drugs and its in-silico evaluation Abstract Isoniazid and Pyrazinamide are the first line anti tubercular drugs. Lactose is mainly used as the excipient in solid dosage forms of isoniazid and pyrazinamide. These drugs contains primary and secondary amino functional group which interacts with lactose by maillard reaction and form adduct. The maillard reaction adducts of isoniazid and pyrazinamide with lactose were synthesized at 60oC in alkaline borate buffer pH 9.2 and characterized by UV, FT-IR, DSC, HPLC and MS. Docking study for in-sillico evaluation of isoniazid-lactose adduct and pyrazinamide-lactose adduct was performed to study its effect on pharmacological activity. The present study shows the presence of incompatibility between isoniazid and pyazinamidewith lactose which leads to loss the therapeutic effect of isoniazid and pyrazinamide. Keywords: isoniazid, pyrazinamide, lactose, maillard reaction, excipient, incompatibility, dosage form. Introduction Excipients are traditionally better known as promoters of degradation than as stabilizers of drug substances (Crowley 1999). Physicochemical and physiological process e.g. stability, physiological pH, gastrointestinal transit time, disintegration, dissolution, permeability and bioavailability can be altered by drug excipient interaction (Jackson, Young et al. 2000). The interactions of drug with excipients can leads to changes in the chemical, physical and therapeutic properties can be termed as incompatibilities (Chadha and Bhandari 2014) and it may cause the drug degradation (Narang, Desai et al. 2012) and loss of pharmacological activity (Patil and Patil 2013). Lactose is most widely used as the excipient in the solid dosage forms. Lactose is available in different form and different grade with different physical characteristics. Lactose is very popular excipient because of low cost and inertness but in other hand lactose have interaction drug with amino functional group i.e. lact ose undergoes maillard [Monajjemzadeh, 2009]The maillard reaction is named Louis Maillard who reported over 80 years ago that some amine and reducing sugars interact each other and forms brown pigments. The first product of this reaction is simple glycosamine (Wirth, Baertschi et al. 1998). In this study, we attempted to explore the modes of interaction and energy binding of the different isomers of isoniazid adduct, pyrazinamide adduct and also study the biological activity of isoniazid adduct and pyrazinamide adduct compare with the help of various molecular modelling techniques. In treatment of tuberculosis, isoniazid and pyrazinamide are key components of first line regimen (Hemanth, Sudha et al. 2012). Isoniazid is chemically isonicotohydrazide and pyrazinamide is chemically pyrazine-2-carboxamide. Isoniazid and pyrazinamide is susceptible for hydrolysis and oxidation interact with excipient particularly carbohydrate and reducing sugars to form hydrazones. The hydrazone is mainly form by the interaction of isoniazid with lactose. There are also reported incompatibilities between lactose and other drugs containing primary and secondary amino functional group (Haywood, Mangan et al. 2005). In this study we were investigated the interaction between lactose with isoniazid and pyrazinamide for that different analytical technique were used and also done the in-sillico evaluation of isoniazid and pyrazinamide. Materials and methods Materials Isoniazid and Pyrazinamide was generously supplied as a gift sample by Macleods Pharmaceuticals Ltd., Wapi (Gujarat), India. Lactose monohydrate was purchased from Merck, Merck specialtiesPvt.Ltd. Mumbai, India. All other chemicals were of high-performance liquid chromatography (HPLC) and analytical grade. Methods Analytical methods UV-visible spectrophotometry The Ultraviolet-visible spectra of Isoniazid, Pyrazinamide and the Isoniazid–lactose adduct, Pyrazinamide-lactose adductwere recorded on a double beam UV-visible spectrophotometer (UV-1700; Shimadzu, Japan). An accurately weighed quantity of about 10 mg of isoniazid, 10 mg of pyrazinamide, 11.66 mg isoniazid-lactose adduct (equivalent to 10 mg isoniazid), 13.33 mg of pyrazinamide-lactose adduct (equivalent to 10 mg pyrazinamide) each dissolved separately in 100 ml of distilled water. From this, one ml of solution was diluted to 10.0 mL with of distilled water to obtain concentration of 10 ppm. All solutionswere scanned in UV-Visible range at 420 and 490 nm (Yates, Jones et al. 2003). Fourier-Transform infrared spectroscopy The Fourier-transform infrared spectroscopy (FTIR) spectra of isoniazid, pyrazinamide, lactose, a isoniazid–lactose physical mixture, pyrazinamide-lactose physical mixture and the isoniazid–lactose adduct, pyrazinamide-lactose were recorded. The spectra were obtained using the diffuse reflectance scan method using KBr on an FT-IR spectrophotometer (IR Affinity 1; Shimadzu, Japan). The scanning range was 400–4000 cm-1. Each sample was scanned 45 times consecutively to obtain FT-IR spectrum. HPLC analysis The HPLC (Gradient) system used for analysis consisted of Agilent Technologies 1200 series equipment, a G1315D quaternary pump, a G1315D diode array detector and a rheodyne injector fitted with a 20  µL loop. Data were recorded and evaluated using the EZChrome Elite software package. Samples were analyzed using LunaC18 column (250 Ãâ€" 4.6 mm i.d. Ãâ€" 5  µm) (Phenomenex) as stationary phase. The mobile phase was water: methanol (95:05, v/v), flow rate of 0.8 mL/min with detection at 266 nm for isoniazid and 269 nm for pyrazinamide. Differential scanning calorimetry Thermal analysis of Isoniazid, pyrazinamide, isoniazid–lactose adduct and pyrazinamide-lactose was performed by differential scanning calorimetry (DSC) using a TA 6000 Mettler toledo thermal analyzer. Individual samples as well as the Maillard adduct (about 2 mg) were weighed in the DSC aluminum pan and were scanned in the temperature range of 25–300 °C. A heating rate of 10 °C/min was used. The thermograms were reviewed for evidence of interaction. Mass Spectrometry The Mass spectrometry was performed using 410 Prostar binary LC with 500 MS with Electro spray Positive ionization and Negative Ionization mode and Mass range is 50-2000 amu. The Isoniazid-lactose, Pyrazinamide-lactose adduct solution dissolved in mobile phase to obtain concentration about 100 µg/mL. In the positive ion mode with electrospray ionization technique, the sample was analyzed. Determination of lactose in pharmaceutical tablet dosage forms The presence of lactose in DOTs tablets was initially examined according to Indian Pharmacopoeia 2007 by taking 5ml saturated solution of tablet powder and then add 5ml 1 M NaOH, Heat and cool at room temperature finally add potassium cupri tatatarate the solution becomes red color shows presence of lactose. Preparation of adduct Sample Prepared in alkaline borate buffer Accurately weighed quantity of Isoniazid 300 mg (equivalent to dose of isoniazid) and 50 mg lactose monohydrate dissolve in alkaline borate buffer pH 9.2 by stirring and ultrasound in 100 ml round bottom flask. In similar way 750 mg pyrazinamide (equivalent to dose of pyrazinamide) was dissolve with 250 mg lactose monohydrate in alkaline borate buffer pH 9.2 in 100 ml round bottom flask. The cleared solutions were refluxed at 600C for 12 hour on water bath. The reaction mixture filtered was diluted with menthol: water (1:1). The adduct was subjected to HPLC analysis (gradient and isocratic run) and Mass spectrometry (LC-MS) analysis. The intensity of brown color was determined was spectrophotometrically after dissolving weighed quantity in distilled water. Docking study The molecular docking tool, GLIDE (Schrodinger Inc., USA) (2006) was used for ligand docking study. The protein preparation was carried out using ‘protein preparation wizard’ in Maestro 9.0. Result UV-Visible spectroscopy The UV-visible absorption spectrum of the isoniazid–lactose adduct and pyrazinamide–lactose adduct had shown an increase in absorption in the visible range as compared with isoniazid and pyrazinamide in distilled water as the solvent. The increased absorption the visible region (brown color) is due to Melanoidins production as the end products of the Maillard reaction as reported earlier (Shen, Tseng et al. 2007). FT-IR spectroscopy The FT-IR absorption patterns of Isoniazid, Pyrazinamide, lactose, Isoniazid–lactose physical mixture immediately after mixing and pyrazinamide-lactose physical mixture immediately after mixing as well as Isoniazid–lactose adduct, Pyrazinamide-lactose adduct were recorded. The peak at 1678 cm−1 in the IR spectrum of Isoniazid-lactose adduct, 1614 cm−1 Pyrazinamide-lactose adduct can be attributed to the imines formation. The peak of N–H bending is present at 1552 cm−1 and 1583 cm-1 in the IR spectrum of Isonizid and Pyrazinamide and its physical mixture respectively. The peak present in spectrum of Isonizid and Pyrazinamide and its physical mixture are absent in Isoniazid-lactose adduct and Pyrazinamide-lactose adduct both these observations support the formation of adduct. The N–H stretching band of secondary amine appears at 3302 cm−1 and at 3292 cm-1 for Isonizid and Pyrazinamide respectively. The peak for the lactose O–H appears at 3522 cm−1 in the infrared spectra of lactose. The peaks for N–H and O–H stretching appear in the spectrum of the physical mixture, but the peak for N–H disappears in the spectrum of the adduct. This may indicate the reaction of the amine with the red ucing sugar, or it may be due overlapping of N–H stretching peak with that of O–H. The FTIR spectra of Isoniazid, Pyrazinamide, Lactose physical mixture, Isoniazid-lactose adduct and Pyrazinamide-lactose adduct shows an interaction between Isoniazid and Pyrazinamide with lactose leading to the formation of a Maillard product (Pavia et al 2009). Differential scanning calorimetry The DSC thermograms show the presence of melting points for isoniazid and pyrazinamide at 171.61ÃŽ ¿C and 189.55 ÃŽ ¿C. The DSC thermogram of lactose shows the peak at 209.83 ÃŽ ¿C. The adduct shows the disappearance of the melting point peak of isoniazid, pyrazinamide, paracetamol and vildagliptine in adduct samples confirms the formation of adduct. Gradient HPLC analysis Initially a gradient run of water and methanol was performed to obtain preliminary information regarding the unknown peaks in maillard reaction products (Shen, Tseng et al. 2007). The mobile phase was optimized to separate the Isoniazid-lactose adduct and Pyrazinamide-lactose adduct was water: methanol (95:05, v/v) with a flow rate 0.8ml/min at ambient temperature. The Isoniazid-lactose adduct and Pyrazinamide-lactose adduct elutes at 3.833min and 1.613 min respectively. The control samples for isoniazid and pyrazinamide (without lactose) were also analyzed which proves method selectivity. Isocratic HPLC analysis The optimized isocratic HPLC analysis of the Isoniazid-lactose adduct and Pyrazinamide-lactose revealed one extra peak that eluted before Isoniazid and Pyrazinamide elution respectively. Performing analysis under same chromatographic parameters, no another peak was observed in control samples. Mass spectrometry The Isoniazid-lactose and Pyrazinamide-lactose adduct dissolve in mobile phase to obtain drug concentration about 100 µg/ml. In the positive ion mode with electrospray ionization technique, the sample was analyzed. The MS spectra show the precursor ion for Isoniazid-lactose adduct and Pyrazinamide-lactose adduct was protonated molecule ([M+H]+) m/z 463.3 and 448.1 respectively. The Isoniazid-lactose adduct and Pyrazinamide-lactose adduct molecular mass was consistent with Isoniazid-lactose adduct and Pyrazinamide-lactose adduct condensation product respectively. The loss of one water molecule from parent leads to maillard-type condensation product. Docking study Isoniazid In docking study, isoniazid shows binding with ARG-38 amino acid in the selected structure of protein (PDB code: 3I6N) and isoniazid-lactose adduct shows binding with ASN-72, SER-69, SER-173, ALA-134 and PRO-132 amino acid in the selected structure of protein (PDB code: 3I6N) as shown in Table No. 1.1. Pyrazinamide Pyrazinamide shows binding with ALA-131 amino acid in the selected structure of protein (PDB code: 3PL1) and pyrazinamide-lactose adduct shows binding with ASP-133 and LEU-131 amino acid in the selected structure of protein (PDB code: 3PL1). Discussion On the above observation difficulties in the formulating a new pharmaceutical dosage form have often experienced because of the interaction between the lactose and active ingredients itself i.e. isoniazid and pyrazinamide. Although the nature and intensity of this interaction may alter the stability, dissolution rate and consequently absorption of the drug and also affect the pharmacological effect. it indicates that such interactions involving in the formation of the complexes and it studied by different analytical techniques. The UV results shows increased absorption in the visible region (brown color) is due to Melanoidins production as the end products of the Maillard reaction as reported earlier in Shen, Tseng et al. 2007. The FTIR spectra of Isoniazid, Pyrazinamide, Lactose physical mixture, Isoniazid-lactose adduct and Pyrazinamide-lactose adduct shows peak of C=N it shows that formation of a Maillard product. HPLC analysis of the Isoniazid-lactose adduct and Pyrazinamide-lactose revealed one extra peak of impurity or maillard reaction product that eluted before Isoniazid and Pyrazinamide elution respectively. The MS spectra show the precursor ion for Isoniazid-lactose adduct and Pyrazinamide-lactose adduct and it has same molecular weight related to maillard-type condensation product. In the docking study of isoniazid adduct and pyrazinamide adduct shows more binding than isoniazid and pyrazinamide but this is pseudo results because this binding present at hydroxyl group and hydroxyl group are responsible for the increase excretion of the isoniazid and pyrazinamide and it may be reduces the therapeutic effect of isoniazid and pyrazinamide. In spite of that analytical study confirm the occurrence of maillard reaction product in lactose containing solid dosage forms of amino functional group containing drugs but lactose is still preferred as excipient in the isoniazid and pyrazinamide containing anti-tubercular formulation i.e. DOT’s. Conclusion The present study reports that antitubercular drugs i.e. isoniazid and pyrazinamide undergoes maillard reaction and that confirmed by UV, FT-IR, HPLC and MS. The docking study of isoniazid adduct and pyrazinamide adduct more binding than isoniazid and pyrazinamide but it is pseudo results pharmacologically the excretion of isoniazid and pyrazinamide increase and it ultimately reduces the therapeutic activity. A drugs- excipient interaction study can be actively used to the advantage of the formulator to increase the bioavailability of the drug. By compiling the data the use of lactose in the formulation of isoniazid and pyrazinamide, secondary amines needs to reconsideration. References: Chadha, R. and S. Bhandari (2014). Drug–excipient compatibility screening—Role of thermoanalytical and spectroscopic techniques. Journal of pharmaceutical and biomedical analysis87: 82-97. Crowley, P. J. (1999). Excipients as stabilizers. Pharmaceutical science technology today2(6): 237-243. Haywood, A., et al. (2005). Extemporaneous isoniazid mixture: stability implications. Journal of Pharmacy Practice and Research35(3): 181. Hemanth, A. K., et al. (2012). Simple and rapid liquid chromatography method for simultaneous determination of isoniazid and pyrazinamide in plasma. SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS9(1): 13-18. Indian Pharmacopoeia, (2007). Government of India, Ministry of health and family walefare, published by the Indian Pharmacopoeia Commission, Gaziabad; vol. II III, pp. 658, 478, 628, 1009, 1008. Jackson, K., et al. (2000). Drug–excipient interactions and their affect on absorption. Pharmaceutical science technology today3(10): 336-345. MONAJJEMZADEH, F., HASSANZADEH, D., VALIZADEH, H., SIAHI-SHADBAD, M. R., MOJARRAD, J. S., ROBERTSON, T. A. ROBERTS, M. S. 2009b. Compatibility studies of acyclovir and lactose in physical mixtures and commercial tablets. European Journal of Pharmaceutics and Biopharmaceutics, 73, 404-413. Narang, A. S., et al. (2012). Impact of excipient interactions on solid dosage form stability. Pharmaceutical research29(10): 2660-2683. PAVIA, D. L. 2009. Introduction to spectroscopy, CengageBrain. com Patil, D. D. and C. R. Patil (2013). Modification of pharmacological activity of nebivolol due to Maillard reaction. Pharmaceutical development and technology18(4): 844-851. Petrella, Stà ©phanie Gelus-Ziental, Nathalie Maudry, Arnaud Laurans, Caroline Boudjelloul, RachidSougakoff, Wladimir(2011).Crystal structure of the pyrazinamidase of Mycobacterium tuberculosis: insights into natural and acquired resistance to pyrazinamide.PLoS One,6(1):e15785. Singh, Amit K Kumar, Ramasamy P Pandey, Nisha Singh, Nagendra Sinha, Mau Bhushan, AshaKaur, PunitSharma, SujataSingh, Tej P (2010). Mode of Binding of the Tuberculosis Prodrug Isoniazid to Heme Peroxidases BINDING STUDIES AND CRYSTAL STRUCTURE OF BOVINE LACTOPEROXIDASE WITH ISONIAZID AT 2.7 Ã… RESOLUTION.Journal of biological chemistry, 285(2): 1569-1576. Shen, S.-C., et al. (2007). An analysis of Maillard reaction products in ethanolic glucose–glycine solution. Food chemistry102(1): 281-287. Wirth, D. D., et al. (1998). Maillard reaction of lactose and fluoxetine hydrochloride, a secondary amine. Journal of pharmaceutical sciences87(1): 31-39. Yates, E. A., et al. (2003). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. Journal of Materials Chemistry13(9): 2061-2063.

Homers The Odyssey :: Analysis Odyssey

I. Preliminary Information A. The name of the book I read is The Odyssey Translated by W.H.D. Rouse. B. The author of the book is Homer. C. The name of the book's publisher is New American Library. The novel was published in New York City. D. This book was published in August 1999. The original year is not known. E. The edition of this book is Signet Classic. F. The book's translator is W.H.D. Rouse. G. This novel has 271 pages. H. This book is a work of non-fiction. II. Book's Contents A. Fiction B. Non-fiction 1. The general topic of the book is Odysseus trying to get home and people mourning over his absence for twenty years. No one in Ithaca has seen or heard from him. His wife, Penelopeia, and his son, Telemachos, are worried. Since it has been so long, every man in the city is now wooing Penelopeia. 2. The main characters in the novel, The Odyssey, are Odysseus, a man who left his home and family to go fight in Troy and never returned home for twenty years, because of a series of misfortunes. Telemachos, Odysseus's son, who finally, after twenty years, decided to sail the sea in search of anyone who may know anything about his father. Also, there is Penelopeia, Odysseus's wife, who has been waiting for him all this time. Her heart is full of pain and sorrow and all of the men are wooing her for her hand in marriage. There are also several kings who play a part in this novel. They are King Nestor, King Alcinoos, and King Menelaos. Lastly, one of the minor, but still important characters is the swineherd, whom let Odysseus stay in his home when he returned from his long and tiring journey. 3. The chief place in which the novel's actions occur is in Ithaca. Some other places in which actions take place are the Island of Aeaea, Island of the Sirens, and the Island of Helios.

gatmoral Moral Responsibility in The Great Gatsby :: Great Gatsby Essays

Moral Responsibility in The Great Gatsby Bang! Gatsby's dead! George Wilson shot Gatsby! However, who is morally responsible for killing Gatsby? The obvious answer would be George since he pulled the trigger. However, it is clear, if for no other reason than for the unimportance of George in the book, that others were also partly responsible. In The Great Gatsby, by F. Scott Fitzgerald, Tom, Daisy, and George are morally responsible for the death of Gatsby. Tom, because of his tattling on Gatsby, can be morally blamed for the murder of Gatsby. When George talked to him, Tom told George it was Gatsby's car that hit Myrtle, but he failed to mention that it was Daisy driving. Even though it was never directly mentioned, it is shown that Tom knew Daisy was the one who killed Myrtle when Nick said, "...and anybody would have said that they were conspiring together," (p.146) when referring to Tom and Daisy talking in their house. This "conspiring" was probably a plan to get Daisy away from the whole incident. Furthermore, Tom and Daisy leave town the next day, proving Tom's knowledge of Daisy's guilt by just trying to escape with her. Even knowing this, Tom still had the indecency to tell George it was Gatsby's car. Tom can also be morally blamed for the killing of Gatsby because of his affair with Myrtle. George killed Gatsby not only because he thought he killed Myrtle, but also because he was under the impression that Gatsby was the one having the affair with his wife. Tom knew George was thinking this and when George talked to him, Tom seized his opportunity to get off the hook for his sin and directed it to Gatsby, making himself even more morally incorrect for doing it. It is clearly justifiable to blame Tom for Gatsby's death. Daisy can also be put morally responsible for Gatsby's death. Her bad morals relating to Gatsby's death are displayed when Gatsby said, "Anyhow - Daisy stepped on it. I tried to make her stop, but she couldn't..." (p.145) Daisy was not morally responsible enough to stop the car after she hit Myrtle. She would also not take the rap for driving the car later, but instead, left town.

Alice Walker Essay -- essays research papers

Alice Walker   Ã‚  Ã‚  Ã‚  Ã‚  Alice Walker is an African American essayist, novelist and poet. She is described as a â€Å"black feminist.†(Ten on Ten) Alice Walker tries to incorporate the concepts of her heritage that are absent into her essays; such things as how women should be independent and find their special talent or art to make their life better. Throughout Walker’s essay entitled â€Å"In Search of Our Mothers’ Gardens,† I determined there were three factors that aided Walker gain the concepts of her heritage which are through artistic ability, her foremothers and artistic models.   Ã‚  Ã‚  Ã‚  Ã‚  Ã¢â‚¬Å"In Search of Our Mothers’ Gardens† touches mainly upon family heritage and the way her heritage was created. In Atwan’s Ten on Ten, you will find the essay on the Mothers’ Gardens. On page 83 it states, â€Å"For they were going nowhere immediate, and the future was not yet within their grasp.† This quote signifies how mothers and grandmothers would always be set serving the men in their lives; for their entire lives, however, there was a different future, a plan that they didn’t see yet. This plan was for them to identify their artistic ability, whether if it was through singing, writing or making quilts.   Ã‚  Ã‚  Ã‚  Ã‚  Throughout the essay, â€Å"In Search of Our Mothers’ Gardens,†Alice Walker’s mentions her foremothers. Women like Jean Toomer, Phillis Wheatley and Zora Neale Hurtson, who were all either poets or writers. Mike Fike has also reco...

Kraft Foods Essay

They offer delicious foods and beverages for every lifestyle on the go. While exploring the website of Kraft seems to define their product mix as foods that are geared more towards the people on the go. I would define their product mix as health/wellness foods, quick fix meals, snacks and beverages as well as offering a Premium line of foods. In their health/wellness foods they offer products in a â€Å"light† form such as things like Philadelphia light cream cheese and reduce fat cookies. For meals on the go or quick fix meals Kraft have designed meals like the Kraft Mac & Cheese Cups, frozen meals and sandwich kits. They offer a wide variety of snack foods including everyone’s favorite cookie Oreo’s and Splendips. The Premium line that Kraft offers includes foods like DiGornio Pizza and Oscar Myer bacon. Kraft offers 8 product lines with over 50 different brands. Kraft’s product mix is the offering of their premium foods, such as DiGornao Ultimate Pizza which is made as a higher quality pizza then the standard. Tombstone Mexican Style Pizza is offered as a convenience food as a favorite food of teenage boys. It was designed for the ease of cooking a easy, quick, healthy meal. Tang is real fruit goodness of oranges. Everyone will surely love its sweet, refreshing flavor plus the added nutrition it gives. It is also instant drink mix offering the convenience food again. South Beach Diet foods are part of their healthy yet, convenience foods. The line offers alternatives to other popular diet fads. South Beach Diet foods play on wholegrain and the correct or right fats like canola oil and olive oil. In this line they also offer bars for a fast way to fill a craving during the day.

Will the Internet Make the World Closer Argumentetive Essay

Will the Internet Make the World Closer Argumentetive Essay Saleh Alansari [email  protected] com Sunday,Oct 28 , 2012 One press of a button on your laptop can show you another world. Internet makes many of changes at several of scopes, such as obtainig credible sourses and developing huge range of commissinons (Wellman, 2002). For example, the high commission of developing the transportation, education, tourism, and presenting the civilization from country to another country (Wellman, 2002).Nowadays, the internet is already a part of our society (Wellman, 2002). In the 1970s, an international network of networks had been created and then computers, telephone lines, and radio networks had finally started working (Poole, & Schuyler, & Senft, 1999). After these developments, would human’s life be completely transformed? Even though there are different levels of technology around the world, Wellman mentions the levels do not matter about the Internet’s impact on both soc ieties and individuals today (Wellman, 2002).The Internet will make the world closer in business, communication and education. First of all, there are many ways that will improve business by Internet and the technology. Internet can lead businessman or businesswomen to communicate with their workers easily. As well as it can help people to find a great business. Internet in these days is very important for many people, notably businessman or businesswoman. However, that is significant for a lot of other, such as people who do not have enough money to travel to find new businesses and featured for many of them.What has the Internet developed in our business? Is not too hard to answer this question if we look at the development of ordering, accounting, selling, advertising, and managing (Michal, 1997). Businessman or businesswomen can easily see themselves only as consumers whose participation is limited to purchasing decision that together add up to a market force pushing one way or another to develop their business (Zittrain, 2008). In short, the Internet has encouraged people to develop their businesses in easy way.Second, people who usually using the Internet are more likely to use the Internet in a variety of social activities and to communicate with friends and family members (Wellman, 2002). The presence of the Internet is important in many things, such as access to resources, social interaction, and communication to local community and outside community (Wellman, 2002). People these days are traveling and mostly of people are studying outside of their own countries in order to achieving at least one of their dreams. At the same time, they always like to have a connection with their friends and families.They are lucky because they are in the era of globalization, developed Internet and the evolution in this world of technology day by day. Now, everyday we hear about a new device of specializing in telecommunications, such as iPhones, Galaxy, etc and it is clearly connected to the Internet server. Most people who use the internet say that the Internet has increase their communication between family members and friends as well as it has a unique quality as a communication channel and the ability to easily connect with others who has similar interest, values, and beliefs. (John, & Katelyn, & McKenna, 2004).Third, there are many reasons that help to say online education is great in someway, such as accessible 24 hours and student-centered teaching. The Internet leads students to study whenever and wherever they want (Online Education Database, 2012). For example, they can travel for their pleasures or businesses and they do not need to focus on their fixed schedules like they should attend their classes on time. Student-centered teaching means everyone has his or her own way to study (Alan, 2009). For instance, some people are more likely to learn online and everyone has his or her owns reasons.Moreover, children can no longer lie to th eir parents about their home works and grades because their schools post those in their web pages and the parents are able to figure out those through the Internet (Michal, 1997). Many students find that they have learned about each other by the Internet also they can reach each other by, emailing and chatting (Wellman, 2002). Students now have great opportunities to study easier more than students before but students in future will have more opportunities to study more easily. Some people might say that the Internet will not make the world closer.It is not closely with each other. For example, when they speak to each other on Skype or chat on Facebook they are not close enough to each other. Also, It might have high possible to increase social and psychological problems (Kimberly, 1999). As well as the Internet can affect decline of ethical people. It is showing many negative subjects. For example, porno websites, which are showing naked bodies, are becoming normal to see by many p eople (Muhammad, 1999). Of course misinformation is developed a lot on Internet (Anne, 2002). Therefore, some people use the Internet as a force to falsify many topics.For example, some websites are present that shows false information about religions, culture and medicine (Anne, 2002). Using Internet incorrectly causes some disadvantages to people such as losing time or having social and psychological problems (Kimberly, 1999). Spending a huge time by using Internet means exactly people waste their time. For instance, many people are using their much time for watching YouTube and looking at Facebook constantly (CNN, 2009) Lots of people especially in Canada check their Facebook every hour (Education, 2009).Also, Internet can cause people to have social serious issues. For example, many people around the world get isolation by people who can use Internet a lot and the isolated people eventually lose their social abilities. For example, they spend much time connecting with each other by texting instead of connecting face to face. Therefore, isolation might cause a psychological problem like depression. However, it is not close to each other but at least they have a way to talk freely and with out pay any money.People should control and solve these problems especially for our new upcoming generations. Also, people who writing false information on the Internet about culture and religious need to solve their problems because that means the exactly meaning of psychological problems (Anne, 2002). Isolation problems are not coming from the Internet only. Many people have those problems with out any effect of Internet. The development of business, education, communication, and civilization are explaining the huge of range benefits we got of the Internet.People spend too much time on the Internet should reschedule their times to avoid social and psychological problems (Kimberly, 1999). To sum up, the Internet had improved our lives in businesses, communication with oth ers, and education. Nowadays, we live with huge growth of technology and anything people want can get it easily by Internet. When we think about how much has the Internet changed in our society, we can look closely at the development for lots of things, such as business, education, communication, civilization, and commission.This shows that the Internet helps to develop our globalization more and more. Also, it explains how the Internet can be one of the biggest helpful services we have in our civilizations. Internet is a helpful and powerful force for doing our work but it can be detrimental, such as a decrease of ethics, an increase of misinformation and sometimes a waste of time. The Internet might be caused some problems, such as social, psychological, and isolation. However, to avoid those problems people should reschedule their times and think about it more seriously before their problems evolve. ReferencesAlan. Pritchard. (2009). Ways of Learning. From http://books. google. c a/books? hl=en&lr=&id=PD2YE3FOpXEC&oi=fnd&pg=PP1&dq=ways%5C+of+learning+&ots=wHs90mPIeG&sig=1sy3LdTKT9wulVFRxkazqExPoY0 Anne P. Mintz. (2002). Web of Deception: Misinformation on the Internet. Fromhttp://books. google. ca/books? hl=en&lr=&id=uS3p9iDooc8C&oi=fnd&pg=PR13&dq=misinformation+is+developed+a+lot+on+Internet. +&ots=tFqFhq60LF&sig=KP4TYnTMtaw9lvTr9G9GCIWiwc8#v=onepage&q=misinformation%20is%20developed%20a%20lot%20on%20Internet. &f=false CNN.Five Clues That you are Addicted to Facebook. Relative April 23, 2009 http://www. cnn. com/2009/HEALTH/04/23/ep. facebook. addict/#cnnSTCVideo Dr. Kimberly S. Young. (1999). Internet Addiction Symptoms, Evaluation, And Treatment. From http://www. netaddiction. com/articles/symptoms. pdf Education. (Nov 1, 2009). Addicted to Facebook?!. From http://www. youtube. com/watch? v=a7MorwJIPCE Hilary Poole, Tami Schuyler, and Theresa M, Senft. (1999). History of the Internet. ABC-CLIO. United States of America. John, A, Bargh & Katelyn, Y, & McKe nna, A. (2004). The Internet and Social Life.From http://www. yale. edu/acmelab/articles/Internet_and_Social_Life. pdf Michal L, Dertouzos, (1997), What Will Be, HarperEdge, United States of America. Muhammad, Hozien. (1999). Pornography and Ethics. William Paterson University. From http://www. muslimphilosophy. com/mih/ethics/e5. htm Online Education Database. Tuesday 10th January 2012. 10 Advantages to Taking Online Classes. From http://oedb. org/library/distance-vs-local/10-advantages-to-taking-online-classes Wellman, B, & Haythornthwaite, C. (2002). The Internet in Everyday Life. Blackwell Publishing. United Kingdom. Will the Internet Make the World Closer Argumentetive Essay Will the Internet Make the World Closer Argumentetive Essay Saleh Alansari [email  protected] com Sunday,Oct 28 , 2012 One press of a button on your laptop can show you another world. Internet makes many of changes at several of scopes, such as obtainig credible sourses and developing huge range of commissinons (Wellman, 2002). For example, the high commission of developing the transportation, education, tourism, and presenting the civilization from country to another country (Wellman, 2002).Nowadays, the internet is already a part of our society (Wellman, 2002). In the 1970s, an international network of networks had been created and then computers, telephone lines, and radio networks had finally started working (Poole, & Schuyler, & Senft, 1999). After these developments, would human’s life be completely transformed? Even though there are different levels of technology around the world, Wellman mentions the levels do not matter about the Internet’s impact on both soc ieties and individuals today (Wellman, 2002).The Internet will make the world closer in business, communication and education. First of all, there are many ways that will improve business by Internet and the technology. Internet can lead businessman or businesswomen to communicate with their workers easily. As well as it can help people to find a great business. Internet in these days is very important for many people, notably businessman or businesswoman. However, that is significant for a lot of other, such as people who do not have enough money to travel to find new businesses and featured for many of them.What has the Internet developed in our business? Is not too hard to answer this question if we look at the development of ordering, accounting, selling, advertising, and managing (Michal, 1997). Businessman or businesswomen can easily see themselves only as consumers whose participation is limited to purchasing decision that together add up to a market force pushing one way or another to develop their business (Zittrain, 2008). In short, the Internet has encouraged people to develop their businesses in easy way.Second, people who usually using the Internet are more likely to use the Internet in a variety of social activities and to communicate with friends and family members (Wellman, 2002). The presence of the Internet is important in many things, such as access to resources, social interaction, and communication to local community and outside community (Wellman, 2002). People these days are traveling and mostly of people are studying outside of their own countries in order to achieving at least one of their dreams. At the same time, they always like to have a connection with their friends and families.They are lucky because they are in the era of globalization, developed Internet and the evolution in this world of technology day by day. Now, everyday we hear about a new device of specializing in telecommunications, such as iPhones, Galaxy, etc and it is clearly connected to the Internet server. Most people who use the internet say that the Internet has increase their communication between family members and friends as well as it has a unique quality as a communication channel and the ability to easily connect with others who has similar interest, values, and beliefs. (John, & Katelyn, & McKenna, 2004).Third, there are many reasons that help to say online education is great in someway, such as accessible 24 hours and student-centered teaching. The Internet leads students to study whenever and wherever they want (Online Education Database, 2012). For example, they can travel for their pleasures or businesses and they do not need to focus on their fixed schedules like they should attend their classes on time. Student-centered teaching means everyone has his or her own way to study (Alan, 2009). For instance, some people are more likely to learn online and everyone has his or her owns reasons.Moreover, children can no longer lie to th eir parents about their home works and grades because their schools post those in their web pages and the parents are able to figure out those through the Internet (Michal, 1997). Many students find that they have learned about each other by the Internet also they can reach each other by, emailing and chatting (Wellman, 2002). Students now have great opportunities to study easier more than students before but students in future will have more opportunities to study more easily. Some people might say that the Internet will not make the world closer.It is not closely with each other. For example, when they speak to each other on Skype or chat on Facebook they are not close enough to each other. Also, It might have high possible to increase social and psychological problems (Kimberly, 1999). As well as the Internet can affect decline of ethical people. It is showing many negative subjects. For example, porno websites, which are showing naked bodies, are becoming normal to see by many p eople (Muhammad, 1999). Of course misinformation is developed a lot on Internet (Anne, 2002). Therefore, some people use the Internet as a force to falsify many topics.For example, some websites are present that shows false information about religions, culture and medicine (Anne, 2002). Using Internet incorrectly causes some disadvantages to people such as losing time or having social and psychological problems (Kimberly, 1999). Spending a huge time by using Internet means exactly people waste their time. For instance, many people are using their much time for watching YouTube and looking at Facebook constantly (CNN, 2009) Lots of people especially in Canada check their Facebook every hour (Education, 2009).Also, Internet can cause people to have social serious issues. For example, many people around the world get isolation by people who can use Internet a lot and the isolated people eventually lose their social abilities. For example, they spend much time connecting with each other by texting instead of connecting face to face. Therefore, isolation might cause a psychological problem like depression. However, it is not close to each other but at least they have a way to talk freely and with out pay any money.People should control and solve these problems especially for our new upcoming generations. Also, people who writing false information on the Internet about culture and religious need to solve their problems because that means the exactly meaning of psychological problems (Anne, 2002). Isolation problems are not coming from the Internet only. Many people have those problems with out any effect of Internet. The development of business, education, communication, and civilization are explaining the huge of range benefits we got of the Internet.People spend too much time on the Internet should reschedule their times to avoid social and psychological problems (Kimberly, 1999). To sum up, the Internet had improved our lives in businesses, communication with oth ers, and education. Nowadays, we live with huge growth of technology and anything people want can get it easily by Internet. When we think about how much has the Internet changed in our society, we can look closely at the development for lots of things, such as business, education, communication, civilization, and commission.This shows that the Internet helps to develop our globalization more and more. Also, it explains how the Internet can be one of the biggest helpful services we have in our civilizations. Internet is a helpful and powerful force for doing our work but it can be detrimental, such as a decrease of ethics, an increase of misinformation and sometimes a waste of time. The Internet might be caused some problems, such as social, psychological, and isolation. However, to avoid those problems people should reschedule their times and think about it more seriously before their problems evolve. ReferencesAlan. Pritchard. (2009). Ways of Learning. From http://books. google. c a/books? hl=en&lr=&id=PD2YE3FOpXEC&oi=fnd&pg=PP1&dq=ways%5C+of+learning+&ots=wHs90mPIeG&sig=1sy3LdTKT9wulVFRxkazqExPoY0 Anne P. Mintz. (2002). Web of Deception: Misinformation on the Internet. Fromhttp://books. google. ca/books? hl=en&lr=&id=uS3p9iDooc8C&oi=fnd&pg=PR13&dq=misinformation+is+developed+a+lot+on+Internet. +&ots=tFqFhq60LF&sig=KP4TYnTMtaw9lvTr9G9GCIWiwc8#v=onepage&q=misinformation%20is%20developed%20a%20lot%20on%20Internet. &f=false CNN.Five Clues That you are Addicted to Facebook. Relative April 23, 2009 http://www. cnn. com/2009/HEALTH/04/23/ep. facebook. addict/#cnnSTCVideo Dr. Kimberly S. Young. (1999). Internet Addiction Symptoms, Evaluation, And Treatment. From http://www. netaddiction. com/articles/symptoms. pdf Education. (Nov 1, 2009). Addicted to Facebook?!. From http://www. youtube. com/watch? v=a7MorwJIPCE Hilary Poole, Tami Schuyler, and Theresa M, Senft. (1999). History of the Internet. ABC-CLIO. United States of America. John, A, Bargh & Katelyn, Y, & McKe nna, A. (2004). The Internet and Social Life.From http://www. yale. edu/acmelab/articles/Internet_and_Social_Life. pdf Michal L, Dertouzos, (1997), What Will Be, HarperEdge, United States of America. Muhammad, Hozien. (1999). Pornography and Ethics. William Paterson University. From http://www. muslimphilosophy. com/mih/ethics/e5. htm Online Education Database. Tuesday 10th January 2012. 10 Advantages to Taking Online Classes. From http://oedb. org/library/distance-vs-local/10-advantages-to-taking-online-classes Wellman, B, & Haythornthwaite, C. (2002). The Internet in Everyday Life. Blackwell Publishing. United Kingdom.

Developmental Disabilities

Developmental disabilities may become apparent before the age of 22 and thus may cause physical or mental limitations. Developmental abilities involve mental retardation, epilepsy, autism, cerebral palsy and other neurological impairments. In the result people may have either limited mobility or limited ability to take care of their physical needs. Nowadays people suffering from developmental abilities, especially in older age, face social challenges, though have the opportunity to enjoy a full and active life.All they need is understanding, encouragement and readiness of family members to help them to become part of their community. Therefore the project will work out new initiatives and ideas how to expand and strengthen the support system of family. Furthermore, the project will provide better understanding of management and support of family members and will contain relevant materials to share with families. Moreover, the project aims at assisting in future planning, trusts, will s and guardianship.The study thus will provide unique knowledge about elder people suffering from developmental disabilities. The objectives of the study are to improve family- directed support and to provide technical assistance in defining personal needs, plans as well as implementation of programs and evaluation of the results. Furthermore, the specific goals of the research is to strengthen programs aimed at providing families with abilities and proper knowledge how to take care of elder members suffering from developmental disabilities.The present project will be assessed through the methods of description, case study and desktop research. A literature search revealed over 150 articles and books on the managing and supporting people with developmental disabilities. Over two-thirds of these were prescriptive and written by practitioners, consultants and journalists. There is also a steady flow of research and ideas on how to improve the quality of family support. References Hollins S, Sireling L. (1990). Working Through Loss with People Who Have Learning Disabilities. Windsor: NFER-Nelson. Kloeppel D, Hollins S. (1989). Mental Retardation and Death in the Family. Death Studies, 13, 31-38. Stroebe, M., Storebe, W., Hansson, R. (1993). Handbook of Bereavement. Cambridge, England: Cambridge University Press.